Bioprocessing & Bioanalytics


Biomonitoring & Biobanks

  • planning, organization and management of sampling events of human and environmental samples
  • collection and documentation of medical history data, diary habits, life circumstances and lifestyle as well as further information on exposure relevant behaviour using standardized questionnaires
  • standardized analysis of clinical chemical parameters of human samples (blood, plasma, 24-hour urine collection)
  • biometrical characterization of human and environmental samples
  • development of protocols for biometrical sample characterization
  • sample preparation and cryopreservation
  • cryopreservation, cryostorage and administration of collected human and environmental samples
  • transport of samples under cryogenic conditions
  • statistical evaluation and interpretation of chemical and clinical data, data on body burden and medical history and biometrical data
  • elaboration and optimization of standard operating procedures (SOPs) according to ISO EN DIN/IEC 17025
  • operation of the cryo-repository of the German Environmental Specimen Bank (ESB) at Münster/Wolbeck
  • isolation and cultivation of adult stem cells of skin and inner organs of different animal species
  • characterization of adult stem cells of animal origin
  • cryopreservation and cryostorage of adult stem cells of animal origin

Biological Processing & Infrastucture

  • Working with cells, microorganisms and clinical samples up to BSL-3
  • establishment of biobanks (including cryopreservation, storage and distribution/shipment)
  • establishment and application of pseudovirus and reporter virus systems
  • antiviral drug efficacy studies
  • determination of immune responses (cellular and antibody-based)
  • development and automation of cell-based assays and process flows (QM-compliant)
  • optimization and validation of biological processes and procedures (QM-compliant)
  • establishment of cell cultures, cell expansion, cell characterization, cell quality control, gene expression analyses
  • biocompatibility studies
  • implementation of quality assurance programs and establishment of standard operation procedures (SOP)

Preclinical Nanomedicine

Preclinical testing of nanoparticular formulations

  • Examination of the interaction of nanomaterials with and crossing of biological barriers (e. g. blood-brain-barrier, intestinal barrier, skin and lung barrier) from primary and stem cells
    • measurement of transendothelial electrical resistance (TER) using impedance spectroscopy
    • radionuclide-based assays
  • implementation of suitable cell culture models for specific tumour targeting
  • establishment of stem cell-based 3D cell culture models (e. g. organoids)
  • proof of cellular uptake and subcellular distribution
  • release, recovery and activity studies of incorporated ingredients
  • drug screening, vascularization studies and cytotoxicity studies at HET-CAM system (Hen` s Egg Test on chorioallantoic membrane)
  • portfolio of cell lines and primary cell-based models for nanotoxicological studies
  • cytotoxicity studies according to ISO 10993/EN 30993
  • radionuclide-based and immunological assays

Production of nanoparticular transport systems

  • Production of biocompatible protein- and polymer-based nanoparticular transport systems for e. g., RNA, DNA, proteins or drugs
  • modification of nanoparticles with e. g., antibodies, peptides or polymers
  • physicochemical characterization of colloidal and nanoparticular formulations


REACH – Toxicological assessment by international standards

  • Assessment of the toxic potential of nanomaterials, chemicals, new materials and medical products
    • toxicological standard assessment according to REACH-test procedures (EG 440/2008)
    • acute & sub-chronic toxicity studies according to international standards (ISO, OECD)
    • studies for genotoxicity, neurotoxicity, cancerogenity, mutagenity
    • cytotoxicity studies (according to ISO 10993-5) and immunotoxicological assessment
    • vascularization test (HET-CAM assay) (Hen` s Egg Test on chorioallantoic membrane)
    • 3R alternatives to animal studies
      • reporter cell-based assays
      • single cell-based assays
      • miniaturized cell-based assays
      • radionuclide-based assays
      • individually developed assays
    • microchip-based toxicity studies
    • physicochemical characterization of (nano)materials and degradation products
    • portfolio of cell line- and primary cell-based models for (nano)toxicological studies

Route of entry of nanoparticles in the organism

  • Investigation of human and ecotoxicological exposure scenarios
    • In-vitro-/ex-vivo-exposure at air-liquid-interfaces (e. g., lung barrier, skin barrier) and at liquid-liquid-interfaces (e. g., intestinale barrier, blood-brain-barrier)
    • In-vitro-and ex-vivo studies of human toxicological effects in the low dose rangeproof of cellular uptake and the sub-cellular distribution in vitro
    • flow cytometry (FACS)
    • confocal Laser-Scanning-Microscopy (CLSM)
    • development of analytical tools for sensitive determination of the environmental fate and characteristics of nanomaterials in low dose range
    • ecotoxicological studies
    • microchip-based systems for cell cultivation and cell analysis
    • 3D, primary, multi cell models, tissue models (e. g. liver)
    • nanotoxicity, chemicals, drug screening
    • compatibility studies of medical products
    • alternative test systems for nanotoxicity studies

Equipment of the Department of Bioprocessing & Bioanalytics

Product Information Sheets Medical Biotechnology

All Publications Medical Bioechnology

Press Releases Medical Biotechnology

Student Works Medical Biotechnology