Biomedical Engineering

Offers

Department Biomedical Microsystems


Microsensors & Microfluidics

  • Biohybrid technology
    - bioimpedance spectroscopy (in vitro and in vivo)
    - sensor systems for medical in vivo diagnostics
    - technologies for the non-destructive characterization, processing and handling of individual cells
    - miniaturized incubation chamber with integrated real-time video monitoring for cell culture
  • Microfluidics and biocell handling systems
    - microfluidic systems as a fluidic interface to biosensors and biochips
    - micro-injection chips for cell injections (needle and pump on a microchip)
  • Microsensors and microactuators
    - mass flow sensors with integrated conductivity measurement
    - sensors for the measurement of film thicknesses (e. g. thickness of a film of saliva in the oral cavity)
    - miniaturized systems, as applicable with wireless actuation/data acquisition
  • Assembly and packaging technology
    - packaging of bioanalysis chips and microimplants
    - design and production of ultrathin (5-10 µm), flexible printed circuit boards with conductor width > 5 µm
    - hybrid-integrated film technologies (thick film, thin film technology) 
  • Thin-film technology
    - deposition of low-stress silicon-nitride films (PECVD)
    - deposition of water-impermeable parylene films
    - deposition of metallic and dielectric films (sputtering)
  • Microstructuring
    - 3D rapid prototyping of SU-8 photo resist using femtosecond laser (structural resolution: 300 nm)
    - photolithography
    - wet chemical etching
    - dry etching (RIE) of parylene C and polyimide, silicon nitride and silicon dioxide
  • Replication technologies
    - silicone moulding
    - rotative hot embossing of (fluidic) microstructures in large-area, continuous polymer films


Biotelemetry

  • wireless telemetry systems for
    - the assessment of physiological and technical signals/parameters
    - biomonitoring
  • control of medical implants
  • use of various technologies
    - inductive (RFID technology)
    - optical, also transcutaneous IR transmission
    - wireless (Bluetooth)
  • development of size-optimized sensor, actuator and communications technology
  • development of electronics especially for biomedical implants
  • optimization of coil geometries for the simultaneous wireless communication, data and energy transmission
  • development of antennae for data transmission (MICS band)


Active Implants

  • conception, design, development and prototyping of active implant systems 
  • application examples in dental and orthopaedic technology, in electrostimulation and sensor technology
  • design and electronic development (hardware and firmware/software) in cooperation with the working groups Biotelemetry and Microsensors & Microfluidics
  • efficient powering of and secure communication with implants
  • encapsulation of active implants (rigid and flexible)
  • in vitro testing of biocompatibility and biostability
  • application of mature and development of new technologies and methods
  • testing in house and in cooperation with certified test houses
  • technical documentation and risk management
  • cooperation with certified medical technology manufacturers and service providers
  • Application examples and competences
    - dental implant to stimulate saliva production
    - dental implant to administer medication via the oral mucosa
    - long-term implantable intracranial pressure sensor
    - shunt system for hydrocephalus therapy
    - active implant for the therapy and rehabilitation of spine disorders
    - wireless control of an implant for electrostimulation of nerves/muscles

 

Department Biomedical Engineering & Neuroprosthetics


Technology

  • customer-specific design, manufacturing and characterization of flexible, implantable polyimide microelectrodes in a wide range of construction forms (e. g. cuff, shaft, sieve, thread, array) and application (e. g. peripheral nerve, ECoG, retina, vestibularis, musculature)
  • coating of the electrode surface to reduce impedance and increase the reversible charge injection capacity
  • evaluation of the long-term reliability of implants (encapsulation materials, electrode layers and supply lines)
  • hybrid assembly and encapsulation of biomedical microimplants
  • mask design for 2D and 3D microelectrodes
  • manufacturing of microimplants with integrated electronics
  • development of dry surface electrodes including material tests and investigations of the transmission behaviour
  • design and manufacturing of recording and stimulation circuits
  • encapsulation of random structures and geometries with parylene
  • rapid prototyping (3D printer, 3D scanner)
  • development and manufacturing of autonomous, distributed sensors and actuators


Methodology

  • development of customer-specific measurement stations for the verification of the long-term stability of implantable structures
  • eye-tracking for usability tests and reading behaviour (high-speed and helmet-based system)
  • registration and analysis of eye movements, vision path and fixation duration for different applications (e. g. while driving vehicles, advertising, design etc.)
  • development of methods and equipment for clinical neurophysiology and psychology including new methods of signal analysis such as online beat-to-beat determination of the pulse transit time, heart rate variability etc.
  • system design of neuroprostheses
  • thermography in the case of technical and biological issues
  • vigilance investigations and registration of emotions in the drive simulator
  • examination of implant materials under physiological conditions and accelerated aging
  • development of stimulation patterns, recording systems, material tests
  • characterization of microelectrodes, material properties of surface electrodes, long-term behaviour of surface electrodes


Consulting

  • consulting on biocompatible coating and encapsulation materials (polyimide, parylene, silicone) and organic electrode material
  • technical assistance for electrophysiological measurements in vitro, in vivo and human
  • investigations on functional electrostimulation and neuromodulation at peripheral nerves
  • implant technology and elaboration of implantation tools for microimplants
  • risk management, quality assurance and verification of the biocompatibility and long-term stability
  • preparation and monitoring of clinical studies


Health Information Systems

  • semantic integration of heterogeneous biomedical data sources
  • long-term archiving solutions for digital medicine
  • semantic search engines in medicine
  • biomedical big data applications
  • clinical expert systems, decision-supporting systems, multivariant data analysis and biostatistics
  • telemedicine platforms for underserved, rural regions and epidemiology
  • information systems for biobanks and their networking
  • integrated information systems for clinical and epidemiological studies
  • disease management systems for domestic and mobile healthcare provision for risk patients, elderly and disabled persons
  • health prevention and rehabilitation systems
  • smart, networked medical devices and intelligent environments
  • medical communication standards (HL7, POCT1A, ICD10, XML, CDISK etc.)
  • near field location and localization systems, asset tracking and management
  • biomedical computer vision solutions

Equipment of the Main Department of Biomedical Engineering

Brochure of Main Department of Biomedical Engineering

Product Information Sheets of the Main Department of Biomedical Engineering

Projects of the Main Department of Biomedical Engineering

All Publicatons of the Main Department of Biomedical Engineering

Press Releases of the Main Department of Biomedical Engineering

Student Works in the Main Department of Biomedical Engineering