From all directions:
Follow the direction to Berlin-Mitte. A public parking garage can be found in Spandauerstrasse 3.
From A24 (north):
Leave the A10 at junction Pankow and follow the A114 to exit Pankow. Continue towards Berlin-Zentrum /Mitte or on the Prenzlauer Allee, which becomes Karl-Liebknecht-Strasse (B2/B5). Turn right into Spandauer Strasse and after 200 m turn left into Anna-Louisa-Karsch-Strasse.
From A2 and A9 (southwest and south):
Leave the A10 at Dreieck Nuthetal and follow the A115 towards Berlin-Zentrum. At Dreieck Funkturm follow direction towards Hamburg/Flughafen Tegel and leave the motorway at the exit Kaiserdamm towards Berlin-Mitte /Tiergarten. Follow the Strasse des 17. Juni and turn to the right in front of the Brandenburg Tor. Then turn left into Behrenstrasse until Glinkastrasse and turn left. At the next intersection, turn right into Unter den Linden. Unter den Linden becomes Karl-Liebknecht-Strasse (B2/B5). Turn left into Spandauer Strasse and after about 200 meters turn left into Anna-Louisa-Karsch-Strasse.
From A13 (east):
Follow the A113 from Schönefelder Kreuz towards Berlin-Grünau/Dreieck Treptow. Continue on the 96a direction to Berlin-Mitte. At the end of Stralauer Allee keep straight into Mühlenstrasse, Holzmarktstrasse, Stralauer Strasse and straight into Spandauer Strasse. After 200 meters turn left into Anna-Louisa-Karsch-Strasse.
Berlin Hauptbahnhof, Zoologischer Garten and Friedrichstrasse:
S-Bahn line S 5, S 7, S 75, S 9 to Hackescher Markt.
Ostbahnhof and Alexanderplatz:
S-Bahn line S 5, S 7, S 75, S 9 to Hackescher Markt. Leave the station towards Burgstrasse/Museumsinsel. Follow Burgstrasse towards the cathedral to Anna-Louisa-Karsch-Strasse, cross it. 20 m further on the left side you will find the main entrance of the SpreePalais.
Airport Berlin Tegel:
The SpreePalais is about 10 km from Berlin's Tegel Airport. The bus line TXL leaves directly from the main hall of the terminal towards Mollstrasse/Prenzlauer Allee. The journey takes about 40 minutes. Go to Spandau Strasse/Marienkirche and cross Karl-Liebknecht-Strasse. Then walk about 150 meters towards Berlin Dom/cathedral and turn off the spree right into the shore walk. The main entrance of the SpreePalais at the cathedral is located on the right side just before Anna-Louisa-Karsch-Strasse.
Airport Berlin Schoenefeld:
The SpreePalais is about 23 km from the Berlin-Schönefeld Airport. At S-Bahn station Berlin Schönefeld Airport take S-Bahn 9 in direction to Spandau. The journey takes about 45 minutes to the station Hackescher Markt. Leave the station towards Burgstrasse/Museumsinsel. Follow Burgstrasse towards Berlin Dom/cathedral to Anna-Louisa-Karsch-Strasse, cross it. 20 meters on the left side you will find the main entrance of the SpreePalais.