Biosensors

• borreliose screening test with BiocoreTM
• low-cost immunosensor for automated detection of e. g. hormones or drugs in whole blood and milk, for drugs in urine, for process control
• fibre optic low-cost immunosensor: plattform for haptene
• in-vitro characterization of molecular targeting ultrasound contrast agent by interaction analysis with human cell lines
• salvia drug test: development of homogeneous immunoassays
• electrochemical detection procedures for biosensors and Lab-on-Chip
• electropoymerisation for functional immobilisation of proteins in thin layers (10-40 nm) in SPR biosensors and electrodes
• kinetic ranking of interactions
• serum screening
• pathway analysis in cells/cell extract
  
• BiocoreTM characterization of antibodies (affinity, cinetics, thermodymanics)
• fluorescence spectroscopic, UV-NIR and electrochemical characterisation of reagents and biomolecules
• dry reagents formulation e.g. for Lab-on-a-Chip (propriatary gel lyophilisation technology)
• examination of storage stability of biosensors, reagents and preparation in clima chamber
• immobilisation of haptenes and proteins on surfaces
• synthesis of fluorescent protein conjugates
• fluidic solutions and construction (3-D-CAD, feasibility studies)
• kinetic ranking of interactions
• antibody characterization
• serum profiling
  

Nanobiotechnology

• high resolution lateral surface structuring of immobilised compounds (»nanostructures«)
• development of nanotechniques by use of biomolecules, single molecule deposition
• PCR on the chip
• DNA-protein interaction analysis
• DNA computing
• surface characterization (scanning probe microscopy, AFM, SNOM,MFM)
• on-chip molecular biology
• structures of peptides an nucleic acids as tools on biochips
• scanning probe microscopy

Microarray & Biochip Technology

• chemical and biochemical coupling on diverse surfaces, e.g., glass and ploymer chips, microtiter plates, membranes
• lateral structuring of biomolecules, biochip design
• development of customised DNA-chips
• peptide chip development
• antibody microarrays
• reverse phase protein microarrays
  
• development of manufacturing techniques for biochip production
• single nucelotide polymorphism (SNP) analysis using dynamic microarrays
• enzyme activity on immobilised substrates
• chemical arrays
• software development
• bioinformatics and data base management
• small scale production of biochips
• biochip technology (practical course)
• bioinformatics (introductary)

Group Laboratory Automation/Systems Integration

In process.

YIG Autonomous Biosensors

• nano- and microencapsulation of biochemicals for controlled release
• design and production of electrochemical cells via rapid prototyping
• design and production of macroscopic capsules, e. g. for housing of biosensors
• compression molding of thermoplastic polymers (PVC, PS, PLGA, etc.)
• biosensor development
• electrochemical characterization of biosensor components
• developments for enzymatic biofuel cells

Biochip Center of Competence

In process.